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Health and Nutrition

Brain Fatty Acid Metabolism and Signaling in Inflammation

Tuesday, May 2, 2023
8:25 AM – 10:30 AM MDT
Room:203

This session will show how eicosapentaenoic acid is a synthesis product of alpha-linolenic acid. These data suggest a critical role for ACSL6-mediated lipid metabolism in synucleinopathies, neurological health, and aging. Another study found that the choroid plexus, a network of blood vessels in each brain ventricle, consumes more arachidonic acid than is renewed, providing another mechanistic explanation of brain inflammation. Also, a presentation will share new insights on the brain’s requirement for dietary alpha-linoleic acid

Presentations:

  • 8:30 AM – 8:50 AM MDT
    DHA incorporation into neuronal membranes is critical for protection against age-related neuroinflammation and neurological disease

    Presenting Author: Jessica M. Ellis, PhD (she/her/hers) – East Carolina University

  • 8:50 AM – 9:10 AM MDT
    Phospholipids containing arachidonic acid are decreased in the choroid plexus during aging which can contribute to inflammation

    Presenting Author: Melanie Plourde, PhD (she/her/hers) – Université de Sherbrooke

    Co-Author: Annick Vachon – Université de Sherbrooke

    Co-Author: Jessica Avila Lopez – Université de Sherbrooke

    Co-Author: Yunping Qiu – - Albert Einstein College of Medicine Michael F. Price Center

    Co-Author: Irwin Kurland – - Albert Einstein College of Medicine Michael F. Price Center

    Co-Author: Benoit Laurent – Université de Sherbrooke

  • 9:10 AM – 9:30 AM MDT
    Unique diet and sex effects on rodent brain oxylipins and implications for dietary α-linolenic acid (ALA) requirements

    Presenting Author: Harold Aukema (he/him/his) – University of Manitoba

  • 9:30 AM – 9:50 AM MDT
    Role of pro-resolving lipid mediator esterification in neurodegenerative brain disorders

    Presenting Author: Ameer Y. Taha (he/him/his) – UC Davis

  • 9:50 AM – 10:10 AM MDT
    Novel methods using natural abundance carbon isotope ratios to study the turnover and metabolism of fatty acids reveals how docosahexaenoic acid regulates its own synthesis

    Presenting Author: Richard P. Bazinet – University of Toronto

    Co-Author: Adam H. Metherel, PhD – University of Toronto

  • 10:10 AM – 10:30 AM MDT
    Panel discussion