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Marie-Caroline Michalski, PhD, Eng. (she/her/hers)

Research Director, Head of DO-IT team of CarMeN laboratory
INRAE, Carmen Laboratory, UMR1397
Pierre Benite, Rhone-Alpes, France

Marie-Caroline Michalski (PhD, Food Eng.), Research Director at the French National Research Institute for Agriculture, Food and Environment (INRAE), is heading the DO-IT Team of CarMeN laboratory "Diet and food matrix in Obesity: role of the Intestinal tract and innovative Therapeutics" (including academic scientists, university professors and clinician MDs). Dr Michalski is interested in the impact of structure and supramolecular organizations of lipids in foods on their health and metabolic effects.
After completing food engineering studies and obtaining a PhD in food science (ENSAIA, Nancy, France, 1992-1998), she has developed research on the structure and functional properties of milk fat and milk fat globules in the Dairy Research Laboratory of INRA (STLO, Rennes, France, 1999-2005). Since 2004, she has developed a new research topic in CarMeN laboratory in Lyon about the impact of lipid structures on their intestinal absorption and metabolic impact, in collaboration with the Human Nutrition Research Center Rhône-Alpes. Her work revealed in humans that lipid digestion comes along with the coabsorption of pro-inflammatory endotoxins naturally present in the gut microbiota, and that this phenomenon is enhanced after a dietary overfeeding period. She revealed in humans that the metabolic fate of dietary fatty acids is different according to the structure of fat ingestion, spread or emulsified, leading to a new concept of “slow vs fast fat” in the nutritional management of obesity-related cardiometabolic risk. Dr Michalski is PI in several national agencies- and industry-funded projects, notably ANR VALOBAB aiming to value buttermilk polar lipids with several potential functional and metabolic benefits (7 partners). In this project, MC Michalski revealed that a dietary supplementation with milk polar lipids reduces lipid markers of cardiometabolic risk in postmenopausal women, with mechanisms involving sphingomyelin and cholesterol fate in the gut. She is also currently studying the metabolic and intestinal impacts of dietary lecithin from different sources.
MC Michalski has been awarded in 2022 the Chevreul Medal, delivered by the French Society for the Study of Lipids to an outstanding researcher for her work in the field of lipid science and industrial applications. The DO-IT team she is heading was awarded by the French Foundation of Medical Research in 2021. Major recent articles were published in journals such as JCI Insight, Gut, Am J Clin Nutr, J Nutr, Mol Nutr Food Res, J Clin Endocr Metab, Prog Lipid Res (h-index=41, ~4000 citations).

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