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Health and Nutrition

Perspectives About the Evidence for the n-3 and n-6 Polyunsaturated Fatty Acid Debate

Tuesday, May 2, 2023
10:55 AM – 1:00 PM MDT
Room:203

The omega-6 and omega-3 debate continues. A talk will explore inconsistent results from major randomized clinical trials with omega-3 fatty acids, which may result from inconsistencies in dose, the nature of the placebos, and background omega-3 intake/blood levels. Another presenter will focus on individual fatty acids and their physiological targets. The session will also explore cross-sectional and prospective studies showing that higher levels of linoleic acid are associated with lower risk for metabolic diseases. Linoleic acid is also the preferred acyl component of cardiolipin in the inner mitochondrial membrane, resulting in higher mitochondrial respiration.

Presentations:

  • 11:00 AM – 11:20 AM MDT
    Blood omega-6s and omega-3 fatty acid levels and risk for cardiovascular disease and diabetes: Results from the FORCE Consortium

    Presenting Author: William S. Harris, PhD – University of South Dakota School of Medicine / Fatty Acid Research Institute

  • 11:20 AM – 11:40 AM MDT
    Addressing the “failed” omega-3 clinical trials: Problems with omega-3 or trial design and execution?

    Presenting Author: Kristina Harris Jackson, PhD, RD (she/her/hers) – Omegaquant Analytics, LLC

  • 11:40 AM – 12:00 PM MDT
    Clinical evidence showing linoleic acid reduces risk for metabolic diseases including type 2 diabetes

    Presenting Author: Martha A. Belury, PhD, RDN (she/her/hers) – The Ohio State University

  • 12:00 PM – 12:20 PM MDT
    Evidence for the negative health effects of excess dietary and circulating linoleic acid

    Presenting Author: Tom Brenna, PhD (he/him/his) – The University of Texas At Austin

  • 12:20 PM – 12:40 PM MDT
    Where do we stand on the omega-6 and omega-3 debate?

    Presenting Author: Philip Calder, PhD, DPhil (he/him/his) – University of Southampton

  • 12:40 PM – 1:00 PM MDT
    Panel discussion